OXIDATIVE STRESS AS MARKER OF POSITIVE SYMPTOMS OF SCHIZOPHRENIA - supports the use of Antioxidants in recovery protocol
"Our study also demonstrates a reduction in superoxide dismutase activity and an increase in protein carbonyl concentration in the CSF of tardive dyskinesia patients. Although they did not pass the statistical test, it is important to discuss the findings in the context of the oxidative stress hypothesis of tardive dyskinesia. Superoxide dismutase is an enzyme critical in the of superoxide, a normal byproduct of oxidative metabolism (32). Attenuated activity of superoxide dismutase may contribute to the increase of oxidized protein."(2.)
" The hypothesis of oxidative damage to striatal neurons mediated by neuroleptic enhancement of glutamatergic neurotransmission is supported by reports that vitamin E reverses the symptoms of tardive dyskinesia; the anecdotal reports have been sustained by double-blind, placebo-controlled studies with vitamin E (43-45). Notably, patients are more responsive to treatment with vitamin E earlier in the course of their disorder, consistent with the model that the oxidative damage is cumulative over time and would involve functional impairment before frank degeneration."(2.)
Links:
http://72.14.203.104/search?q=cache:LHVarP96W18J:facta.junis.ni.ac.yu/facta/mab/mab200202/mab200202-05.pdf+peroxynitrite+schizophrenia&hl=en&gl=us&ct=clnk&cd=8&client=firefox-a
(2.) http://ajp.psychiatryonline.org/cgi/content/full/155/9/1207
One Patient's story of non clinical and clinical diagnosis of Schizophrenic like symptoms, attempts at vitamin therapy approach, seizure activity present. We searched for answers & much of our research was beneficial in chronological context. Taken out of context, the information may not provide an accurate understanding/solution. Psychiatric illness was ruled out. This blog indicates how we arrived @ the current treatment -vitamin therapy. Diagnosis given: Fronto-temporal dementia.
LOW HISTAMINE
- This LOW HISTAMINE schizophrenia supplement schedule was developed to improve the quality of life of our family member-referred to as Patient. Once the FTD diagnosis was agreed, the patient was in late stages and soon hospitalized. The only supplement that was to have significant impact on FTD was DHEA in the early stages. THIS is not a recommendation and we make no claims this protocol will work for you. Always check with a qualified Doctor when making changes to your recovery protocols.
- 100mg L-Carnosine AM - scavenger of oxidative stress (ROS & alpha-beta unsaturated aldehydes), improves processes affected with autisim, found highly concentrated in muscle and brain tissue, quickly metabolizes blood levels of stress produced Cortisol returning levels to normal, too much Carnosine may cause hyperactivity.
- 100mg R-ALA (RLA) PM - Powerful antioxidant, reverse cognitive dysfunction, increases glutathione, "recycles" other key antioxidants such as vitamin C, vitamin E, and glutathione, promotes glucose metabolism, proven effective for treating diabetic neuropathy, prevents nerve damage from oxidation.
- 2mg Melatonin PM-ONLY - counteracts TD, Improves sleep quality of chronic schizophrenia patients, suppresses prolactin release, necessary for SWS-REM sleep, stimulates endorphin production (updated from 1mg 12-9-06)
- 5mg DHEA AM Androgen occurring naturally in humans and synthesized from cholesterol. 5mg maintenance dose-no higher. Patient responded to larger 50mg dose in the past but then had significant side effects. Goal is to balance or restore normal level. Body does not upregulate its own levels when taken orally, so max total levels should not exceed natural 15 mg in body daily.
- 100mg CoQ10 AM Many useful antioxidant activities especially Schizophrenia, neuroprotective effects, potent free radical scavenger in lipid and mitochondrial membranes (increased from 30mg on 2-15-07)
- 800mg EPA-protein AM Balance with DHA
- 200mg Vitamin B6 Pyridoxine AM Counteracts Kryptopyrrole, break down and use fats, proteins, and carbohydrates, to make red blood cells and antibodies, to help the digestive and nervous systems function, maintain healthy skin. Converts to coenzyme P5P in body
- 800mg DHA-protein AM Balance with EPA
- 500mg per meal Vitamin B3 Niacin (no flush-slow release) AM Opens Capillaries, take after each meal, Removes voices, Needed for Omega EFA conversions to prostaglandins.
- 50-80mg Zinc AM Positive Factor for TD, inverse of Copper, Works closely with B6, promotes normal metallothionein, commonly out of balance with Copper
- 200mcg-600mcg Selenium AM Antidote for Mercury, Antioxidant, Antidepressant, Improves Prostaglandins
- 30mg Chelated Manganese PM Prevents Tardive (TD), increases elimination of copper and helps return copper levels to normal. Do not take with Calcium.
- 5,000mcg Vitamin B12 AM Improves RBC flow through Capillaries
- |AVOID| 200mg SAM-e (S-adenosylmethionine) Treats Undermethylation, was tested on this Patient and did not respond well, maintains cell membrane structure, substances vital to transmitting nerve impluses that influence mood and emotion
- |AVOID| 100mg L-Theanine - inhibits glutamic acid excitotoxicity, promotes GABA production, decreases serotonin and increases dopamine (BAD FOR PATIENT), promotes alpha wave production associated with alert relaxation (non drowsy), improves immune system response by boosting capacity of T cells, crosses blood brain barrier.
- Exercise & Diet - 30 minutes of walking per day
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