Patient had dizziness about 15 minutes after raisin bran and soymilk. Called Dr. to get appointment for checking low blood pressure and high sugar levels. Patient may need a glucose stress test. Patient may need to add sugar or wheat free diet. Asked Patient to have Bagel on Dec 1st instead of cereal. Days that begin with dizzy spell seem to be not as good as days that have no dizziness after the morning meal. Supplements taken today, melatonin taken last night.
Patient remarked that dizziness is fading in strength each day.
-gjh
Patient seems to be improving.
Has exrecised, which helps patient stay alert.
Still takes the supplements and that is helping.
Not much eye drooping as before.
Patient still mentions about hearing things or telling me something is amiss but not as often as in the past.
-gwh
Patient was hearing children in the bedroom (this was after it got dark outside) did not know the time? Just happened to walk into the bedroom and Patient was asking about the voices while cph sat in the chair across the room. This may have occurred after eating dinner?
-gwh
Had cph remove SAM-e dose from pill boxes for now as a result of brain trending towards hyperactivity-possible seritonin or receptor enhancement/anti depression. Perhaps exercise is sufficient mood enhancement.
--gjh
Thursday, November 30, 2006
SAM-e for SZ
"Two independent lines of inquiry have implicated some disturbance of one-carbon cycle metabolism in affective disorders. Folic acid deficiency commonly leads to depression, and S-adenosylmethionine has been reported to have antidepressant properties. Methionine adenosyltransferase has been reported to be underactive in depression and schizophrenia and overactive in mania. This study reports the effects on erythrocyte methionine adenosyltransferase (MAT) kinetics (Vmax) of a 2-week treatment in a population of patients housed on a psychiatric research ward. The drug-free schizophrenic patients and depressives had, upon admission, low Vmax values, and the drug-free manic patients had high Vmax values on admission. After 2 weeks of appropriate treatment, the values for all three patient samples showed significant normalization (i.e., the levels rose in schizophrenics and depressives and fell in manics). We have further shown that pretreatment low levels of erythrocyte membrane phosphatidylcholine in depressives and high levels in manics show statistically significant normalization following 2 weeks of pharmacotherapy. The significance of these results is discussed."(1.)
"SAM-E (also known as SAM or AdoMet) is a derivative of the amino acid, methionine. It's formed when methionine combines with adenosine triphosphate (ATP), a nucleotide present in all living cells. ATP is the major source of cellular energy. The liver uses this process to make SAM-E, as much as 8 grams of it every day, when the liver is perfectly healthy. Liver disease, osteoarthritis and the overuse of prescription drugs or over-the-counter medications can diminish the body's production of SAM-E. A small amount of SAM-E is found in food, but it is highly unstable and an unreliable means of increasing blood levels." (2.)
"As a methyl donor, SAM-E "donates" units called methyl groups, which contain hydrogen and carbon atoms, to other substances. This process is called methylation, and it is one way in which the body protects itself from damage on the cellular level."(2.)
SAM-E facilitates the manufacture of brain neurotransmitters
"Methyl donors help to protect against cancer, heart disease, neurological disorders, and many age-related problems, and facilitate the manufacture of DNA and brain neurotransmitters. SAM-E is involved in more than 50 methylation reactions in the body, including the regulation of various hormones and neurotransmitters such as serotonin, melatonin, and dopamine."(2.)
"Once SAM-E donates its methyl group to choline, creatine, carnitine, DNA, RNA, epinephrine, and other compounds, it is transformed into S-adenosyl-homocysteine, (SAH). SAH donates its sulfur molecule to sulfur-containing amino acids such as cysteine, from which glutathione is formed. SAH then gives up its adenosine molecule to yield homocysteine. Homocysteine is a potentially toxic amino acid and an independent risk factor for coronary disease. Folic acid, choline, or betaine can change homocysteine back to methionine in the presence of vitamin B12, or convert homocysteine into cysteine and glutathione in the presence of vitamin B6. For this reason, it is recommended to supplement your diet with vitamin B12 and B6 when taking SAM-E. SAM-E is particularly important for the liver because glutathione is synthesized from it. Glutathione is crucial for liver function. A good portion of liver SAM-E is turned into glutathione. Glutathione is the liver's natural antioxidant."(2.)
"The synthesis of SAMe is intimately linked with folate and vitamin B12 (cyanocobalamin) metabolism, and deficiencies of both these vitamins have been found to reduce CNS SAMe concentrations. Both folate and vitamin B12 deficiency may cause similar neurological and psychiatric disturbances including depression, dementia, myelopathy and peripheral neuropathy. SAMe has a variety of pharmacological effects in the CNS, especially on monoamine neurotransmitter metabolism and receptor systems. SAMe has antidepressant properties, and preliminary studies indicate that it may improve cognitive function in patients with dementia."(3.)
"Several open and double-blind studies suggest that SAMe may have an anti-depressant effect, and further studies are indicated. SAMe may exert a beneficial effect selectively on endogenous rather than neurotic depression. SAMe crosses the blood-brain barrier. SAMe is involved in several central enzyme pathways relating to transmethylation and folate and monoamine metabolism as well as in membrane function and neuro-transmission." (4.)
Links:
(1.) Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes. Smythies JR, Alarcon RD, Morere D, Monti JA, Steele M, Tolbert LC, Walter-Ryan WG. Biol Psychiatry 1986 Dec;21(14):1391-8
http://www.psycom.net/depression.central.same.html
(2.) http://www.healingdaily.com/conditions/sam-e-1.htm
(3.) The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Bottiglieri T, Hyland K, Reynolds EH - Metabolic Disease Center, Baylor Research Institute, Dallas, Texas.
http://www.psycom.net/depression.central.same.html
(4.) S-adenosylmethionine and affective disorder. Carney MW, Toone BK, Reynolds EH - Department of Psychiatry, Northwick Park Hospital, Harrow, England. Am J Med 1987 Nov 20;83(5A):104-6
http://www.psycom.net/depression.central.same.html
--gjh
"SAM-E (also known as SAM or AdoMet) is a derivative of the amino acid, methionine. It's formed when methionine combines with adenosine triphosphate (ATP), a nucleotide present in all living cells. ATP is the major source of cellular energy. The liver uses this process to make SAM-E, as much as 8 grams of it every day, when the liver is perfectly healthy. Liver disease, osteoarthritis and the overuse of prescription drugs or over-the-counter medications can diminish the body's production of SAM-E. A small amount of SAM-E is found in food, but it is highly unstable and an unreliable means of increasing blood levels." (2.)
"As a methyl donor, SAM-E "donates" units called methyl groups, which contain hydrogen and carbon atoms, to other substances. This process is called methylation, and it is one way in which the body protects itself from damage on the cellular level."(2.)
SAM-E facilitates the manufacture of brain neurotransmitters
"Methyl donors help to protect against cancer, heart disease, neurological disorders, and many age-related problems, and facilitate the manufacture of DNA and brain neurotransmitters. SAM-E is involved in more than 50 methylation reactions in the body, including the regulation of various hormones and neurotransmitters such as serotonin, melatonin, and dopamine."(2.)
"Once SAM-E donates its methyl group to choline, creatine, carnitine, DNA, RNA, epinephrine, and other compounds, it is transformed into S-adenosyl-homocysteine, (SAH). SAH donates its sulfur molecule to sulfur-containing amino acids such as cysteine, from which glutathione is formed. SAH then gives up its adenosine molecule to yield homocysteine. Homocysteine is a potentially toxic amino acid and an independent risk factor for coronary disease. Folic acid, choline, or betaine can change homocysteine back to methionine in the presence of vitamin B12, or convert homocysteine into cysteine and glutathione in the presence of vitamin B6. For this reason, it is recommended to supplement your diet with vitamin B12 and B6 when taking SAM-E. SAM-E is particularly important for the liver because glutathione is synthesized from it. Glutathione is crucial for liver function. A good portion of liver SAM-E is turned into glutathione. Glutathione is the liver's natural antioxidant."(2.)
"The synthesis of SAMe is intimately linked with folate and vitamin B12 (cyanocobalamin) metabolism, and deficiencies of both these vitamins have been found to reduce CNS SAMe concentrations. Both folate and vitamin B12 deficiency may cause similar neurological and psychiatric disturbances including depression, dementia, myelopathy and peripheral neuropathy. SAMe has a variety of pharmacological effects in the CNS, especially on monoamine neurotransmitter metabolism and receptor systems. SAMe has antidepressant properties, and preliminary studies indicate that it may improve cognitive function in patients with dementia."(3.)
"Several open and double-blind studies suggest that SAMe may have an anti-depressant effect, and further studies are indicated. SAMe may exert a beneficial effect selectively on endogenous rather than neurotic depression. SAMe crosses the blood-brain barrier. SAMe is involved in several central enzyme pathways relating to transmethylation and folate and monoamine metabolism as well as in membrane function and neuro-transmission." (4.)
Links:
(1.) Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes. Smythies JR, Alarcon RD, Morere D, Monti JA, Steele M, Tolbert LC, Walter-Ryan WG. Biol Psychiatry 1986 Dec;21(14):1391-8
http://www.psycom.net/depression.central.same.html
(2.) http://www.healingdaily.com/conditions/sam-e-1.htm
(3.) The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Bottiglieri T, Hyland K, Reynolds EH - Metabolic Disease Center, Baylor Research Institute, Dallas, Texas.
http://www.psycom.net/depression.central.same.html
(4.) S-adenosylmethionine and affective disorder. Carney MW, Toone BK, Reynolds EH - Department of Psychiatry, Northwick Park Hospital, Harrow, England. Am J Med 1987 Nov 20;83(5A):104-6
http://www.psycom.net/depression.central.same.html
--gjh
Wednesday, November 29, 2006
Lipitor - Glial cell interference
Lipitor passes the blood brain barrier and interferes with cholesterol's roll in providing synaptic connections between neurons. The brain cannot get cholesterol from the blood supply and relies solely on the cholesterol synthesis production by glial cells in the brain.
Patient was taking Lipitor for 30 days and quit the drug as a result of a muscular side effect.
http://www.spacedoc.net/lipitor_thief_of_memory.html
Patient was taking Lipitor for 30 days and quit the drug as a result of a muscular side effect.
http://www.spacedoc.net/lipitor_thief_of_memory.html
Heavy Metal Toxicity
We were told by Patient that at a young age (10), with bare hands, the Patient had played with Mercury from a broken thermometer. So, I am researching what effect Mercury would have on the Patient.
"The "silver" fillings in your teeth - Dental Amalgams - are still widely used by the dental profession in most parts of the world. The "Amalgam" consists of a mix of metals - Generally 50% Mercury, 35% Silver, 15% Tin and other metals. But is it safe to put so much Mercury, the most toxic non-radioactive metal known to man, into the mouth of a person? There is now a growing mountain of evidence that it is NOT safe to do so."(1.)
"Mercury Destroys Brain Cells. Dr. Boyd Haley, Ph.D., a biochemist at the University of Kentucky, is probably one of the world's top experts on mercury toxicity. Hear this fascinating review of the irrefutable evidence that links mercury toxicity to Autism and Alzheimer's disease."(1.)
"Mercury in vaccines - One hundred years ago, children received 1 vaccine (the smallpox vaccine). Forty years ago, children received 5 vaccines routinely (diphtheria, pertussis, tetanus, polio, and smallpox vaccines) and as many as 8 shots by 2 years of age. Children now receive 52 vaccines, in the form of 15 shots, by the time they are 6 months of age if they receive all the recommend shots, including the Prevnar pediatric pneumonia shot. Vaccines contain THIMERSOL (mercury), MSG, aluminum, formaldehyde, sucrose and phenoxyethanol, which is antifreeze, among many other things. Thimerosal, a vaccine ingredient, is nearly 50% mercury. Mercury is a NEUROTOXIN. EPA 'safe' levels are: .1 microgram per 1.0 kilogram of body weight per day. Vaccines contain 12.5 to 25.0 micrograms of mercury, and a 'well baby' visit can see your child have between 50 and 62.5 mcgs of MERCURY injected into their bloodstream. The CDC (US) has found a trend linking autism to mercury laden vaccines. Thimerosal is a registered pesticide with the Department of Pesticide Registration of the Environmental Protection Agency."(1.)
[soon to be completed]
Links of Interest:
http://www.theepochtimes.com/news/6-2-27/38658.html
Mercury Autism http://hatingautism.blogspot.com/2006/10/mercury-caused-autism-epidemic-please.html
(1.) Is Mercury Amalgam Fillings slowly poisoning us?
http://www.shirleys-wellness-cafe.com/amalgam.htm
"The "silver" fillings in your teeth - Dental Amalgams - are still widely used by the dental profession in most parts of the world. The "Amalgam" consists of a mix of metals - Generally 50% Mercury, 35% Silver, 15% Tin and other metals. But is it safe to put so much Mercury, the most toxic non-radioactive metal known to man, into the mouth of a person? There is now a growing mountain of evidence that it is NOT safe to do so."(1.)
"Mercury Destroys Brain Cells. Dr. Boyd Haley, Ph.D., a biochemist at the University of Kentucky, is probably one of the world's top experts on mercury toxicity. Hear this fascinating review of the irrefutable evidence that links mercury toxicity to Autism and Alzheimer's disease."(1.)
"Mercury in vaccines - One hundred years ago, children received 1 vaccine (the smallpox vaccine). Forty years ago, children received 5 vaccines routinely (diphtheria, pertussis, tetanus, polio, and smallpox vaccines) and as many as 8 shots by 2 years of age. Children now receive 52 vaccines, in the form of 15 shots, by the time they are 6 months of age if they receive all the recommend shots, including the Prevnar pediatric pneumonia shot. Vaccines contain THIMERSOL (mercury), MSG, aluminum, formaldehyde, sucrose and phenoxyethanol, which is antifreeze, among many other things. Thimerosal, a vaccine ingredient, is nearly 50% mercury. Mercury is a NEUROTOXIN. EPA 'safe' levels are: .1 microgram per 1.0 kilogram of body weight per day. Vaccines contain 12.5 to 25.0 micrograms of mercury, and a 'well baby' visit can see your child have between 50 and 62.5 mcgs of MERCURY injected into their bloodstream. The CDC (US) has found a trend linking autism to mercury laden vaccines. Thimerosal is a registered pesticide with the Department of Pesticide Registration of the Environmental Protection Agency."(1.)
[soon to be completed]
Links of Interest:
http://www.theepochtimes.com/news/6-2-27/38658.html
Mercury Autism http://hatingautism.blogspot.com/2006/10/mercury-caused-autism-epidemic-please.html
(1.) Is Mercury Amalgam Fillings slowly poisoning us?
http://www.shirleys-wellness-cafe.com/amalgam.htm
Oxidative Stress
OXIDATIVE STRESS AS MARKER OF POSITIVE SYMPTOMS OF SCHIZOPHRENIA - supports the use of Antioxidants in recovery protocol
"Our study also demonstrates a reduction in superoxide dismutase activity and an increase in protein carbonyl concentration in the CSF of tardive dyskinesia patients. Although they did not pass the statistical test, it is important to discuss the findings in the context of the oxidative stress hypothesis of tardive dyskinesia. Superoxide dismutase is an enzyme critical in the of superoxide, a normal byproduct of oxidative metabolism (32). Attenuated activity of superoxide dismutase may contribute to the increase of oxidized protein."(2.)
" The hypothesis of oxidative damage to striatal neurons mediated by neuroleptic enhancement of glutamatergic neurotransmission is supported by reports that vitamin E reverses the symptoms of tardive dyskinesia; the anecdotal reports have been sustained by double-blind, placebo-controlled studies with vitamin E (43-45). Notably, patients are more responsive to treatment with vitamin E earlier in the course of their disorder, consistent with the model that the oxidative damage is cumulative over time and would involve functional impairment before frank degeneration."(2.)
Links:
http://72.14.203.104/search?q=cache:LHVarP96W18J:facta.junis.ni.ac.yu/facta/mab/mab200202/mab200202-05.pdf+peroxynitrite+schizophrenia&hl=en&gl=us&ct=clnk&cd=8&client=firefox-a
(2.) http://ajp.psychiatryonline.org/cgi/content/full/155/9/1207
"Our study also demonstrates a reduction in superoxide dismutase activity and an increase in protein carbonyl concentration in the CSF of tardive dyskinesia patients. Although they did not pass the statistical test, it is important to discuss the findings in the context of the oxidative stress hypothesis of tardive dyskinesia. Superoxide dismutase is an enzyme critical in the of superoxide, a normal byproduct of oxidative metabolism (32). Attenuated activity of superoxide dismutase may contribute to the increase of oxidized protein."(2.)
" The hypothesis of oxidative damage to striatal neurons mediated by neuroleptic enhancement of glutamatergic neurotransmission is supported by reports that vitamin E reverses the symptoms of tardive dyskinesia; the anecdotal reports have been sustained by double-blind, placebo-controlled studies with vitamin E (43-45). Notably, patients are more responsive to treatment with vitamin E earlier in the course of their disorder, consistent with the model that the oxidative damage is cumulative over time and would involve functional impairment before frank degeneration."(2.)
Links:
http://72.14.203.104/search?q=cache:LHVarP96W18J:facta.junis.ni.ac.yu/facta/mab/mab200202/mab200202-05.pdf+peroxynitrite+schizophrenia&hl=en&gl=us&ct=clnk&cd=8&client=firefox-a
(2.) http://ajp.psychiatryonline.org/cgi/content/full/155/9/1207
Update November 29
4:45pm. Just talked to Patient. Exercised today and attempted to eat a tuna fish sandwich for lunch, but only ate a few bites because it "didn't taste right." Says that there are still lingering side effects of the discontinued medication. Other than that, patient sounded well and was able to carry on a conversation without any hesitation. No experiences today of hearing voices.
Patient slept ok last night - no nightmare and took 1mg melatonin before bed. Patient had breakfast (raisin bran and soymilk without dizziness) & supplements today before 10:30 AM. Spoke clearly and quick thinking.
4PM conversation with Patient responded great, excited, happy. Asked patient about playtime activities when Patient was 10 years old, there was no delay in recalling the memory.
A study published Nov 28 2006 suggests that an area of the brain has been found to have shorter pathways in SZ patients. http://www.annals-general-psychiatry.com/content/5/1/19
The PDF of the study, which you may find on the link above, has diagrams and MRI information.
--gjh
Patient slept ok last night - no nightmare and took 1mg melatonin before bed. Patient had breakfast (raisin bran and soymilk without dizziness) & supplements today before 10:30 AM. Spoke clearly and quick thinking.
4PM conversation with Patient responded great, excited, happy. Asked patient about playtime activities when Patient was 10 years old, there was no delay in recalling the memory.
A study published Nov 28 2006 suggests that an area of the brain has been found to have shorter pathways in SZ patients. http://www.annals-general-psychiatry.com/content/5/1/19
The PDF of the study, which you may find on the link above, has diagrams and MRI information.
--gjh
Tuesday, November 28, 2006
Cerebral Allergies
Several standing dizzy spells occurred 30 minutes after eating Raisin Bran and soymilk at 12pm. Supplements had not yet been taken.
--sw
No panic or hallucinations reported today. Patient exercised today. Pills found left in todays box at 7pm. Worked with cph to fully manage the pill box and monitor its use. All other supplements have been removed from access by Patient. Multivitamins were found to contain copper and are removed from Patient's access. Discussed these details with Patient by phone. Had not had dinner yet by 8PM. Verified no hallucinations or voices today. Evening meal was antipasto salad - no dizziness.
--gjh
(1)"Dairy and gluten allergies are common to people with schizophrenia," said Carter, who has headed the Schizophrenia Foundation for nearly 20 years. "I've seen many cases when removing them - a majority of the symptoms will abate. These are confirmed by orthomolecular doctors around the world."
(1) Patricia Lefave - "Nuts R Us News" Blog - DONNA NEBENZAHL, The Gazette - Published: Monday, May 08, 2006
http://pistachiopress.blogspot.com/2006/08/conventional-psychiatry-did-not-help.html
--sw
No panic or hallucinations reported today. Patient exercised today. Pills found left in todays box at 7pm. Worked with cph to fully manage the pill box and monitor its use. All other supplements have been removed from access by Patient. Multivitamins were found to contain copper and are removed from Patient's access. Discussed these details with Patient by phone. Had not had dinner yet by 8PM. Verified no hallucinations or voices today. Evening meal was antipasto salad - no dizziness.
--gjh
(1)"Dairy and gluten allergies are common to people with schizophrenia," said Carter, who has headed the Schizophrenia Foundation for nearly 20 years. "I've seen many cases when removing them - a majority of the symptoms will abate. These are confirmed by orthomolecular doctors around the world."
(1) Patricia Lefave - "Nuts R Us News" Blog - DONNA NEBENZAHL, The Gazette - Published: Monday, May 08, 2006
http://pistachiopress.blogspot.com/2006/08/conventional-psychiatry-did-not-help.html
Vitamin E
"Vitamin E consists of eight different compounds — four tocopherols and four tocotrienols (sic...). A varied diet eaten by humans may contain all eight compounds. The most abundant sources of tocotrienols are the oil fractions from cereal grains, including barley, rice, rye and wheat, and the fruit of the oil palm. Commercial quantities of tocotrienols are currently extracted from palm oil and rice bran oil. Tocopherols are also present in these sources but are more abundant in the oils extracted from soybean, corn (maize), cottonseed and sunflower seed, which are now the primary commercial sources for natural vitamin E products.
Y-Tocopherol appears to be more potent than A-tocopherol in increasing superoxide dismutase (SOD) activity in plasma and arterial tissues as well as manganese SOD and copper/zinc SOD protein expression in arterial tissues. SOD is a major antioxidant enzyme" (1.)
"Benefits for cardiovascular health —
The strongest evidence yet for tocotrienols comes from a clinical study conducted by the Kenneth Jordan Heart Research Foundation in New Jersey, USA. The study, now in its fifth year, has been evaluating 50 patients who had stenosis of the carotid artery. It is appropriate here to explain what stenosis is and the problems associated with its treatment. Stenosis means constriction or narrowing — the accumulation of plaque over time causes stenosis of the arteries. Stenosis of the carotid artery can cause stroke. "(2.)
"In addition to enzymes, the animal cell uses many other chemicals to protect against oxygen free-radicals. Vitamin E is the main free-radical trap in the (lipid) membranes. Vitamin C acts as an anti-oxidant in the non-lipid ("watery") portions of cells, between cells and in the bloodstream. Melatonin, a hormone produced by the pineal gland in decreasing quantities with aging, efficiently crosses membranes (including the nucleus) and is effective against hydroxyl radicals." (3.)
(1.) Li, D. et al. (1999) Relative effects of Y- and A-tocopherol on low-density lipoprotein oxidation and superoxide dismutase and nitric oxide synthase activity and protein expression in rats. Cardiovasc. Pharmacol. Ther., 219–226.
(2.) Watkins, T.R. et al. (1998) Tocotrienols: biological and health effects. In: Antioxidant Status, Diet, Nutrition and Health, (see ref. 2) pp.479–496.
(3.) THE FREE RADICAL THEORY OF AGING, Ben Best
http://www.benbest.com/lifeext/aging.html#radical
Y-Tocopherol appears to be more potent than A-tocopherol in increasing superoxide dismutase (SOD) activity in plasma and arterial tissues as well as manganese SOD and copper/zinc SOD protein expression in arterial tissues. SOD is a major antioxidant enzyme" (1.)
"Benefits for cardiovascular health —
The strongest evidence yet for tocotrienols comes from a clinical study conducted by the Kenneth Jordan Heart Research Foundation in New Jersey, USA. The study, now in its fifth year, has been evaluating 50 patients who had stenosis of the carotid artery. It is appropriate here to explain what stenosis is and the problems associated with its treatment. Stenosis means constriction or narrowing — the accumulation of plaque over time causes stenosis of the arteries. Stenosis of the carotid artery can cause stroke. "(2.)
"In addition to enzymes, the animal cell uses many other chemicals to protect against oxygen free-radicals. Vitamin E is the main free-radical trap in the (lipid) membranes. Vitamin C acts as an anti-oxidant in the non-lipid ("watery") portions of cells, between cells and in the bloodstream. Melatonin, a hormone produced by the pineal gland in decreasing quantities with aging, efficiently crosses membranes (including the nucleus) and is effective against hydroxyl radicals." (3.)
(1.) Li, D. et al. (1999) Relative effects of Y- and A-tocopherol on low-density lipoprotein oxidation and superoxide dismutase and nitric oxide synthase activity and protein expression in rats. Cardiovasc. Pharmacol. Ther., 219–226.
(2.) Watkins, T.R. et al. (1998) Tocotrienols: biological and health effects. In: Antioxidant Status, Diet, Nutrition and Health, (see ref. 2) pp.479–496.
(3.) THE FREE RADICAL THEORY OF AGING, Ben Best
http://www.benbest.com/lifeext/aging.html#radical
Monday, November 27, 2006
Melatonin, DHEA for SZ
In our Patient, TD presents itself as a long closure of the eye lids as if the Patient was asleep. If you engage the Patient in conversation you find the Patient awake and responding and when you discuss a topic the Patient is excited about, the Patient will open the eyes. Patient is aware that eyes are closed and describes them as being clamped shut.
--gjh
"A common side effect of antipsychotic medications used to treat schizophrenia is a condition called tardive dyskinesia, a movement disorder of the mouth characterized by a constant chewing motion and darting action of the tongue. In a study(1.) of 22 people with schizophrenia and tardive dyskinesia caused by antipsychotic medications, those who took melatonin supplements had significantly reduced mouth movements compared to those who did not take the supplements."
(2.) "antipsychotics produce their effect by reducing DHEA." "DHEA naturally begins to decline around age twenty to twenty-five, and this probably occurs earlier in schizophrenics. In addition to this decline, interference with the availability of DHEA may occur because of another adrenal hormone, cortisol, and, beginning at puberty, the hormone, testosterone."
"In my articles on evolution and sleep at this website, I connect the pineal hormone, melatonin, with DHEA. I suggest melatonin may be involved in producing receptors, chemical doorways, for DHEA. For DHEA to produce its growth promoting activities on neurons, it must have a pathway into the neuron. Melatonin stimulates these receptor at night. I think this pathway is reduced in schizophrenics, because nighttime melatonin is reduced in schizophrenia (Biological Psychiatry 1989, 25: 500). Proper amounts of melatonin are necessary for slow wave sleep to occur; the deepest stage of slow wave sleep is stage 4. Lack of stage 4 sleep is documented in schizophrenia. (sic) ...others think reduced melatonin may be involved in some forms of schizophrenia, however, the investigators do not mention DHEA."
"The drugs used to control schizophrenia, I suggest, actually exert their effects by stimulating DHEA production. That is, "...antipsychotic potencies of most neuroleptic drugs closely correspond to their prolactin-releasing potencies at low doses..." (Biological Psychiatry 1990, 27: 1204). Therefore, it may actually be DHEA that ameliorates schizophrenia upon antipsychotic drug administration. Schizophrenia is thought to result from dopaminergic over-activity; essentially all antipsychotic drugs block postsynaptic dopamine receptors. This increases prolactin release. The dopaminergic agonist, bromocriptine, often used as an anti-prolactin agent, produces hallucinations, delusions, and confused thinking when used in excess."
"Schizophrenia results from lack of cerebral hemisphere growth as a result of severe reductions in DHEA and melatonin during brain growth and development. It is triggered by events later in life that reduce DHEA availability and increase the negative effects of cortisol. I suggest treating schizophrenics with melatonin at night and DHEA during the day may help in some circumstances, depending on the level of damage done by prolonged cortisol exposure."
(3.)"Cortisol also inhibits hippocampal neurogenesis, but DHEA has a stimulatory effect. Cortisol can actually kill hippocampal neurons, and does so increasingly with aging and stress, but this effect can be reversed with melatonin and Insulin-like Growth Factor (IGF-1) [THE JOURNAL OF NEUROSCIENCE; Aberg,MA; 20(8):2896-2903 (2000)]."
Useful Links:
http://www.umm.edu/altmed/ConsSupplements/Melatonincs.html
http://www.anthropogeny.com/Schizophrenia.htm
http://www.benbest.com/nutrceut/melatonin.html
http://www.benbest.com/nutrceut/DHEA.html
(1.)Shamir E, Barak Y, Shalman I, Laudon M, Zisapel N, Tarrasch R, et al. Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Arch Gen Psych. 2001;58(11):1049-1052.
(2.)James Michael Howard - http://www.anthropogeny.com/Schizophrenia.htm
(3.) Chapter 3 -- Learning, Memory and Plasticity, by Ben Best
http://www.benbest.com/science/anatmind/anatmd3.html
--gjh
"A common side effect of antipsychotic medications used to treat schizophrenia is a condition called tardive dyskinesia, a movement disorder of the mouth characterized by a constant chewing motion and darting action of the tongue. In a study(1.) of 22 people with schizophrenia and tardive dyskinesia caused by antipsychotic medications, those who took melatonin supplements had significantly reduced mouth movements compared to those who did not take the supplements."
(2.) "antipsychotics produce their effect by reducing DHEA." "DHEA naturally begins to decline around age twenty to twenty-five, and this probably occurs earlier in schizophrenics. In addition to this decline, interference with the availability of DHEA may occur because of another adrenal hormone, cortisol, and, beginning at puberty, the hormone, testosterone."
"In my articles on evolution and sleep at this website, I connect the pineal hormone, melatonin, with DHEA. I suggest melatonin may be involved in producing receptors, chemical doorways, for DHEA. For DHEA to produce its growth promoting activities on neurons, it must have a pathway into the neuron. Melatonin stimulates these receptor at night. I think this pathway is reduced in schizophrenics, because nighttime melatonin is reduced in schizophrenia (Biological Psychiatry 1989, 25: 500). Proper amounts of melatonin are necessary for slow wave sleep to occur; the deepest stage of slow wave sleep is stage 4. Lack of stage 4 sleep is documented in schizophrenia. (sic) ...others think reduced melatonin may be involved in some forms of schizophrenia, however, the investigators do not mention DHEA."
"The drugs used to control schizophrenia, I suggest, actually exert their effects by stimulating DHEA production. That is, "...antipsychotic potencies of most neuroleptic drugs closely correspond to their prolactin-releasing potencies at low doses..." (Biological Psychiatry 1990, 27: 1204). Therefore, it may actually be DHEA that ameliorates schizophrenia upon antipsychotic drug administration. Schizophrenia is thought to result from dopaminergic over-activity; essentially all antipsychotic drugs block postsynaptic dopamine receptors. This increases prolactin release. The dopaminergic agonist, bromocriptine, often used as an anti-prolactin agent, produces hallucinations, delusions, and confused thinking when used in excess."
"Schizophrenia results from lack of cerebral hemisphere growth as a result of severe reductions in DHEA and melatonin during brain growth and development. It is triggered by events later in life that reduce DHEA availability and increase the negative effects of cortisol. I suggest treating schizophrenics with melatonin at night and DHEA during the day may help in some circumstances, depending on the level of damage done by prolonged cortisol exposure."
(3.)"Cortisol also inhibits hippocampal neurogenesis, but DHEA has a stimulatory effect. Cortisol can actually kill hippocampal neurons, and does so increasingly with aging and stress, but this effect can be reversed with melatonin and Insulin-like Growth Factor (IGF-1) [THE JOURNAL OF NEUROSCIENCE; Aberg,MA; 20(8):2896-2903 (2000)]."
Useful Links:
http://www.umm.edu/altmed/ConsSupplements/Melatonincs.html
http://www.anthropogeny.com/Schizophrenia.htm
http://www.benbest.com/nutrceut/melatonin.html
http://www.benbest.com/nutrceut/DHEA.html
(1.)Shamir E, Barak Y, Shalman I, Laudon M, Zisapel N, Tarrasch R, et al. Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Arch Gen Psych. 2001;58(11):1049-1052.
(2.)James Michael Howard - http://www.anthropogeny.com/Schizophrenia.htm
(3.) Chapter 3 -- Learning, Memory and Plasticity, by Ben Best
http://www.benbest.com/science/anatmind/anatmd3.html
SZ Subtypes
Patient took supplements today. No known thought disorder today.
I'm researching subtype of SZ based on memories of Patients past symptoms and pre SZ symptoms. Indications are High Histamine and/or Pyroluria. Patient had history of quick acting, swelling skin reactions to scratches or insect bites. Chronic pre-med SZ symptoms include temper outbursts, delusional thinking, mood swings, anxiety, depression - Patient was misdiagnosed depressed.
useful links:
http://www.hriptc.org/BioTreatment.html
http://answers.yahoo.com/question/index?qid=20061013040917AAWqglK
-gjh
There is a strong possibility that Patient is suffering from an undetected allergy that has affected the brain (a cerebral allergy). Patient experienced highly allergic reaction to eating ice cream 5 years ago and had to go to the hospital. At one point in Patient's past, there was a craving for cottage cheese and frozen yogurt. We've discovered in our research that most often the foods we are allergic to are often times the same foods that we crave. There's a chance that the Patient has become more intensely allergic to dairy products over time and that may have brought on the SZ symptoms because of the body's inability to cope with the allergy. The allergy left undetected may have created what has seemed to appear to be a chronic condition. Dairy molecules can have a negative impact on the brain in those who are allergic to it. Beginning yesterday, consumption of dairy products was stopped for a period of time. We will monitor Patient over the next week or so to see if/how SZ symptoms improve.
Some very interesting allergy information is available at the following link: http://www.springboard4health.com/notebook/health_food_addiction.html
--sw
I'm researching subtype of SZ based on memories of Patients past symptoms and pre SZ symptoms. Indications are High Histamine and/or Pyroluria. Patient had history of quick acting, swelling skin reactions to scratches or insect bites. Chronic pre-med SZ symptoms include temper outbursts, delusional thinking, mood swings, anxiety, depression - Patient was misdiagnosed depressed.
useful links:
http://www.hriptc.org/BioTreatment.html
http://answers.yahoo.com/question/index?qid=20061013040917AAWqglK
-gjh
There is a strong possibility that Patient is suffering from an undetected allergy that has affected the brain (a cerebral allergy). Patient experienced highly allergic reaction to eating ice cream 5 years ago and had to go to the hospital. At one point in Patient's past, there was a craving for cottage cheese and frozen yogurt. We've discovered in our research that most often the foods we are allergic to are often times the same foods that we crave. There's a chance that the Patient has become more intensely allergic to dairy products over time and that may have brought on the SZ symptoms because of the body's inability to cope with the allergy. The allergy left undetected may have created what has seemed to appear to be a chronic condition. Dairy molecules can have a negative impact on the brain in those who are allergic to it. Beginning yesterday, consumption of dairy products was stopped for a period of time. We will monitor Patient over the next week or so to see if/how SZ symptoms improve.
Some very interesting allergy information is available at the following link: http://www.springboard4health.com/notebook/health_food_addiction.html
--sw
Sunday, November 26, 2006
Blog Launch November 26, 2006
Natural medicine approach to Schizophrenia - herein referred to as SZ. A daily progress of a family member we refer to as "patient" who is starting the orthomolecular protocol. Entries will be done by family members reporting their observations of the patient.
Patient began assortment of supplements yesterday. Patient reported nightmare from the 1mg Melatonin taken before bed a few days ago and hasn't taken it since. Dream recall may be a positive effect of supplementation whether nightmare or not. The full program began at Day 0.
-7PM Patient questions family about cars missing from driveway (not missing.)
Family Practice Dr.:
Margolis, Steven, MD - Alternacare
43956 Mound Rd., Sterling Heights, MI 48314
Phone: (586) 323-1122
NOTE: This nutritional schedule is under development and is NOT developed or yet reviewed by the family doctor. The information used to create the schedule was pulled from many hours of research. Posts will be updated and corrected when necessary.
Personal note: There is no single source for this information, there is no one person you can talk to, one book you can read, one doctor to visit. This is why we are providing the total information we have found that deals with our unique SZ case. In the event it helps even one family, it will be worth the effort. While it is necessary to accurately document the progress of this method, we will include information that is research oriented for understanding deficiencies, symptoms, and methods for improving the quality of life and restoring the biochemical health. Clearly, the drugs available today (2006) mask the symptoms and present significant risk of serious side effects.
--gjh
useful links:
http://en.wikipedia.org/wiki/Orthomolecular_medicine
http://en.wikipedia.org/wiki/Orthomolecular_psychiatry
In the past, the Patient has taken Miatake, CoQ10, DHEA, copper and Lecithin. SZ is said to be found in people with high copper levels! Patient was taking copper as directed by doctor to help improve a separate health issue. Over a month ago the Patient was still taking Omega 3's, Lecithin and some B vitamins, as well as taking Niacin and small dose of DHEA. Patient has stopped taking copper.
Psychiatric history: Patient developed delusional thinking 2003, with hallucinations occurring 2006. Patient was prescribed Lexapro for depression. Insurance company changed prescription to Celexa. Following administration of Celexa, patient's SZ symptoms became more intense. Patient then visited a different doctor and was diagnosed with Paranoid SZ and prescribed 1 mg of Respirdal. Patient became very lethargic. Thinking and speaking ability slowed down significantly. After 2 weeks of these side effects, patient was switched to 5 mg of Abilify. Strange behaviors and paranoia, audible and sensory hallucinations increased. Then dosage was increased to 20 mg. Eyes began to droop involuntarily. Violent hallucinations experienced. Continuous delusional thinking and thought disorder continued with no relief. Experienced dizziness, backache and metallic taste in mouth often. Ironically, delusional thinking and hallucinations were observed a half hour after patient ingested the Abilify drug (a drug that is supposed to reduce those very symptoms).
20 mg of Abilify was discontinued after 6 weeks. Catatonic demeanor and what appears to be Tardive (heavy eyes, long face-lack of emotion) still present a week later.
--sw
Patient began assortment of supplements yesterday. Patient reported nightmare from the 1mg Melatonin taken before bed a few days ago and hasn't taken it since. Dream recall may be a positive effect of supplementation whether nightmare or not. The full program began at Day 0.
-7PM Patient questions family about cars missing from driveway (not missing.)
Family Practice Dr.:
Margolis, Steven, MD - Alternacare
43956 Mound Rd., Sterling Heights, MI 48314
Phone: (586) 323-1122
NOTE: This nutritional schedule is under development and is NOT developed or yet reviewed by the family doctor. The information used to create the schedule was pulled from many hours of research. Posts will be updated and corrected when necessary.
Personal note: There is no single source for this information, there is no one person you can talk to, one book you can read, one doctor to visit. This is why we are providing the total information we have found that deals with our unique SZ case. In the event it helps even one family, it will be worth the effort. While it is necessary to accurately document the progress of this method, we will include information that is research oriented for understanding deficiencies, symptoms, and methods for improving the quality of life and restoring the biochemical health. Clearly, the drugs available today (2006) mask the symptoms and present significant risk of serious side effects.
--gjh
useful links:
http://en.wikipedia.org/wiki/Orthomolecular_medicine
http://en.wikipedia.org/wiki/Orthomolecular_psychiatry
In the past, the Patient has taken Miatake, CoQ10, DHEA, copper and Lecithin. SZ is said to be found in people with high copper levels! Patient was taking copper as directed by doctor to help improve a separate health issue. Over a month ago the Patient was still taking Omega 3's, Lecithin and some B vitamins, as well as taking Niacin and small dose of DHEA. Patient has stopped taking copper.
Psychiatric history: Patient developed delusional thinking 2003, with hallucinations occurring 2006. Patient was prescribed Lexapro for depression. Insurance company changed prescription to Celexa. Following administration of Celexa, patient's SZ symptoms became more intense. Patient then visited a different doctor and was diagnosed with Paranoid SZ and prescribed 1 mg of Respirdal. Patient became very lethargic. Thinking and speaking ability slowed down significantly. After 2 weeks of these side effects, patient was switched to 5 mg of Abilify. Strange behaviors and paranoia, audible and sensory hallucinations increased. Then dosage was increased to 20 mg. Eyes began to droop involuntarily. Violent hallucinations experienced. Continuous delusional thinking and thought disorder continued with no relief. Experienced dizziness, backache and metallic taste in mouth often. Ironically, delusional thinking and hallucinations were observed a half hour after patient ingested the Abilify drug (a drug that is supposed to reduce those very symptoms).
20 mg of Abilify was discontinued after 6 weeks. Catatonic demeanor and what appears to be Tardive (heavy eyes, long face-lack of emotion) still present a week later.
--sw
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