Phosphatidylserine (PS)

I found an excellent brief on Phosphatidylserine located at the link below. I did not find anything to suggest it would increase seizure activity, so I may introduce it for its list of benefits.

"PS is a fat-soluble nutrient and would be expected to require at least several days' dosing to build up in the nerve cell membranes." "PS appears in the blood at about 30 minutes. After a few more minutes uptake begins into the liver and, later, the brain." "Given orally, PS is rapidly absorbed and readily crosses the blood-brain barrier to reach the brain. There, its sites of action appear to be exclusively in cell membrane." "Structurally, PS protected the hippocampus (a major memory center) from the loss of dendrite connections that normally occurs with aging (see Nunzi et al, 1987)." "Nunzi and co-workers (1992) found that in the rat hippocampus, a fall-off in nerve growth factor receptor density occurs with aging. PS reversed this receptor density decline and seemed to enhance NGF production." "PS given to these athletes prior to starting exercise produced an impressive degree of down-regulation of the stress hormones"(1)

Regarding dosing: "A reasonable supplementation strategy with PS is to begin at 300 mg per day with meals for a month, then go into a maintenance mode at a lower level of intake (100 to 200 mg daily). There is no indication of potential problems from long-term supplementation with PS."(1)

"As a general rule, because PS is so safe the more severe the subject's problems the more aggressive can be the supplementation strategy. Patients with severe memory problems can be kept on all their other supplements and medications, and be given PS with their meals at 300 to 500 mg per day on an ongoing basis. Subjects afflicted with motor problems may respond better at 500 mg per day. Mood problems may require a starting dose of 400 mg per day. For age-related cognitive decline (ARCD), a daily intake of 300 mg may be appropriate. "(1)


(1) "Phosphatidylserine, A Remarkable Brain Cell Nutrient"
http://www.springboard4health.com/books_online/ps/phosphatidylserine.html

--gjh